NAD+
NAD+ (Nicotinamide Adenine Dinucleotide)
Research Parameters
- Typical Dose Range
- Subcutaneous: 100 to 300 mg per administration, 1 to 3 times weekly. IV (research clinics): 250 to 1000 mg per infusion.
- Half-Life
- Complex. NAD+ itself has a short plasma half-life; tissue accumulation varies.
- Administration Route
- Subcutaneous, Intravenous, Intranasal, Oral
Dosing information is for research purposes only and has not been evaluated by the FDA.
NAD+ is the molecule every serious longevity researcher ends up talking about. It's the cofactor your cells need to produce energy, repair damaged DNA, and run the sirtuin pathway that David Sinclair's research made famous. Levels drop by roughly 50% between your 30s and your 60s in some tissues, and that decline tracks with most of the things people notice about aging: lower energy, slower recovery, cognitive softness, reduced metabolic flexibility.
Technical note: NAD+ itself isn't a peptide. It's a coenzyme. It gets grouped with peptide protocols because it's administered the same way and researched in the same longevity context. Research covers mitochondrial function, cognitive performance, metabolic health, and longevity endpoints. The real research distinction to understand: direct NAD+ administration versus precursor supplementation (NR, NMN). Each has its own pharmacokinetic profile and the research literature supports both rather than declaring a winner.
For research purposes only.
Mechanism of Action
NAD+ is the central electron-transfer coenzyme in cellular metabolism, essential for ATP production, sirtuin activation, and PARP-mediated DNA repair. Direct administration bypasses the conversion steps required when using precursors (NR, NMN). Intracellular NAD+ regulates over 500 enzymatic reactions involved in energy metabolism, DNA repair, and gene expression.
Citations
Frequently Asked Questions
- What is NAD+ used for in research?
Research covers mitochondrial function, cellular energy, DNA repair, sirtuin activation, and longevity endpoints. It's the central cofactor in the biological energy system. For research purposes only.
- Is it better to supplement NAD+ directly or use NR/NMN precursors?
Research supports both approaches with different pharmacokinetic profiles. Direct NAD+ achieves higher plasma levels; precursors cross cell membranes more easily but require conversion. The research literature doesn't declare a winner. It's endpoint-dependent. For research purposes only.
- How does NAD+ compare to SS-31 for longevity research?
NAD+ supports mitochondrial function through the energy cofactor pathway; SS-31 protects the mitochondrial membrane from damage. Different failure modes of mitochondrial aging, often studied together. For research purposes only.