Selank
Selank (TP-7)
Research Parameters
- Typical Dose Range
- 250 to 300 mcg/day intranasal (research standard)
- Half-Life
- ~1 hour (plasma); CNS effects persist longer
- Administration Route
- Intranasal
Dosing information is for research purposes only and has not been evaluated by the FDA.
Selank is what the research points toward when the question is: how do I take the edge off without getting dulled? Benzodiazepines reduce anxiety but kill focus, cause dependency, and produce withdrawal. Selank appears to reduce anxiety without any of that. That's a meaningful difference, and it's why Selank is in serious research rotation for high-stress, high-performance contexts.
Russia approved Selank clinically for generalized anxiety. Research outside Russia covers the same endpoints plus stress resilience, cognitive performance under pressure, and immune modulation. Researchers often stack it with Semax because the mechanisms complement: Semax sharpens cognition, Selank reduces the anxiety that impairs it.
For research purposes only.
Mechanism of Action
Selank is a synthetic heptapeptide derived from tuftsin, a natural immunomodulatory peptide. It modulates GABA indirectly while also affecting serotonin and BDNF signaling. That indirect approach is what the research links to anxiety reduction without the sedation and dependency of direct GABA-A binders like benzodiazepines.
Citations
Frequently Asked Questions
- What is Selank used for in research?
Research covers anti-anxiety effects, stress resilience, focus under load, and immune modulation. It's the research-world alternative to benzodiazepines studied for its lack of sedation and dependency. For research purposes only.
- How does Selank compare to benzodiazepines?
Benzodiazepines bind directly to GABA-A receptors, producing sedation and dependency risk. Selank modulates GABA indirectly while also affecting serotonin and BDNF. The research suggests anxiety reduction without sedation or withdrawal. For research purposes only.
- Can Selank be stacked with Semax in research protocols?
Yes. They're commonly studied together. Semax targets cognition, Selank targets anxiety, and the research literature shows complementary rather than overlapping mechanisms. For research purposes only.