Epithalon
Epithalon (Ala-Glu-Asp-Gly)
Research Parameters
- Typical Dose Range
- 5 to 10 mg daily for 10 to 20 days, 1 to 2 times per year (Russian research standard)
- Half-Life
- ~30 minutes (plasma)
- Administration Route
- Subcutaneous, Intranasal
Dosing information is for research purposes only and has not been evaluated by the FDA.
Epithalon is the peptide people talk about when they bring up telomeres, the protective caps on your chromosomes that shorten with every cell division and are one of the cleanest biological markers of aging anyone has identified. Researchers study Epithalon specifically for its effects on telomerase, the enzyme that rebuilds those caps. It's the reason Epithalon is the headline longevity peptide in the research world.
The other thing the research keeps finding: Epithalon regulates melatonin and circadian rhythm in ways that correlate with better sleep and slower age-related decline. Most of the strongest human data comes from long-duration Russian studies. Vladimir Khavinson published on this for three decades. Western journals reference that work constantly but rarely replicate it at scale.
For research purposes only.
Mechanism of Action
Epithalon is a synthetic four-amino-acid peptide modeled on Epithalamin, a natural pineal gland extract. Its primary characterized mechanism is telomerase activation, with additional effects on melatonin regulation and gene expression. Research protocols run 10 to 20 days, 1 to 2 times per year, because the effects on gene expression persist far longer than the peptide itself.
Citations
Frequently Asked Questions
- What is Epithalon used for in research?
Research focuses on telomerase activation, pineal gland function, melatonin regulation, and longevity endpoints. The telomere research is the strongest reason it's studied in anti-aging contexts. For research purposes only.
- Why are Epithalon research protocols so short?
Most published protocols run 10 to 20 days, 1 to 2 times per year, because research shows the downstream effects on gene expression persist far longer than the peptide itself. Continuous dosing isn't supported by the literature. For research purposes only.
- How does Epithalon compare to NAD+ for longevity research?
Epithalon targets telomere length and gene expression; NAD+ targets mitochondrial and DNA repair function. Different longevity mechanisms. They're studied as complements rather than substitutes. For research purposes only.